Efficacy and safety of once-daily dapsone 7.5% gel monotherapy for mild to moderate acne vulgaris: A comparative study with adapalene 0.1% gel monotherapy
Abstract Objective: To see the efficacy and safety of once daily dapsone 7.5% gel for mild to moderate acne vulgaris compared with adapalene 0.1% gel monotherapy. Methods: This was a randomized, open-label, comparative study, conducted over 47 patients with mild to moderate acne (lesional count 3-30). Patients were randomly enrolled into two 2 treatment groups (A and B). They were instructed to apply a thin layer of dapsone 7.5% gel (group A, n=23) or adapalene 0.1% gel (group B (n=24) on face. Inflammatory, non-inflammatory and total lesions were counted and adverse effects were assessed at weeks 0, 4, 8 and 12. Result: All forms of acne lesions were reduced from baseline to onwards in both groups. Percent reduction of total lesions and non-inflammatory acne lesions were statistically similar in both groups (p>0.05) but for inflammatory lesions, dapsone 7.5% gel is less effective than adapalene 0.1% gel (p<0.05). Adverse effects were also indifferent between the two groups (p>0.05). Conclusion: Dapsone 7.5 gel is effective and safe as monotherapy for acne vulgaris. Keywords: Dapsone, Adapalene, Acne vulgaris |