Original Article
Efficacy and safety of once-daily dapsone 7.5% gel monotherapy for mild to moderate acne vulgaris: A comparative study with adapalene 0.1% gel monotherapy
Author Details
1. Consultant, Dept. of Dermatology and Venereology, Dhaka Medical College, Dhaka, Bangladesh.
2. Assistant Professor, Dept. of Dermatology and Venereology, Care Medical College, Dhaka, Bangladesh.
3. Data analyst, National heart foundation Bangladesh, Dhaka, Bangladesh.
4. Consultant, Dept. of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.
5. Associate Professor, Dept. of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.
Abstract Objective: To see the efficacy and safety of once daily dapsone 7.5% gel for mild to moderate acne vulgaris compared with adapalene 0.1% gel monotherapy. Methods: This was a randomized, open-label, comparative study, conducted over 47 patients with mild to moderate acne (lesional count 3-30). Patients were randomly enrolled into two 2 treatment groups (A and B). They were instructed to apply a thin layer of dapsone 7.5% gel (group A, n=23) or adapalene 0.1% gel (group B (n=24) on face. Inflammatory, non-inflammatory and total lesions were counted and adverse effects were assessed at weeks 0, 4, 8 and 12. Result: All forms of acne lesions were reduced from baseline to onwards in both groups. Percent reduction of total lesions and non-inflammatory acne lesions were statistically similar in both groups (p>0.05) but for inflammatory lesions, dapsone 7.5% gel is less effective than adapalene 0.1% gel (p<0.05). Adverse effects were also indifferent between the two groups (p>0.05). Conclusion: Dapsone 7.5 gel is effective and safe as monotherapy for acne vulgaris. Keywords: Dapsone, Adapalene, Acne vulgaris |
Keywords: Dapsone, Adapalene, Acne Vulgaris