Scabies,how difficult to treat- A systematic review

Abstract

Background: Scabies is a neglected tropical disease that continues to have global impacts and long-term health consequences in all nations regardless ofsocial and economic status.Treatment failure is an important factor concerning the increase in scabies incidence over the last decade. Here, we present an updatedreview of scabies by focusing on the challenges and difficulties in treatment that prevent the efforts foradequate control of the disease. Methods:The Cochrane Database of Systematic Reviews, MEDLINE, SCOPUS, Google Scholar, PubMed, and MEDLINE were all used in a systematic search. We incorporated case-control studies, prospective or retrospective cohorts, randomized and quasi-randomized trials, longitudinal (one-arm) observational studies, and case series that were published in the previous ten years. Our search terms included "vaccine," "mass drug administration," "scabies," "Sarcoptes scabiei var. hominis," "treatment," "management," "research updates," and "outcomes." Studies that discussed treatment resistance, failure, and difficulties in treating scabies were included. To gather information on global scabies control initiatives, obstacles, and experiences, as well as knowledge gaps, needs assessments, and recommendations for the future, a literature search was conducted. The papers that were included were only published in English. Results: For the systematic review, a total of 26 studies met the eligibility requirements. Drug resistance, application errors (especially with topical agents), neglecting repeated treatments, insufficient compliance, reinfestation due to insufficient decontamination of the patient's environment, failing to treat contacts concurrently, and not providing written information about necessary measures are among the established reasons why treating scabies can be challenging. Conclusion: Scabies is a highly contagious parasitic cutaneous disease that is stigmatizing and debilitating. Increased awareness, accurate diagnosis, prompt treatment, and selecting the right treatment options are essential for the effective control of scabies and for the prevention of the spread of the disease. Abbreviation: NTD, MDT, IACS

Keywords: Scabies, treatment, failure, challenges.